Title : The molecular basis of isolated 17,20 lyase deficiency.

Pub. Date : 1998 Aug-Nov

PMID : 9888582






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Human P450c17 catalyzes the 17alpha-hydroxylation of pregnenolone to 17OH pregnenolone and of progesterone to 17alpha-OH progesterone; the same P450c17 enzyme also catalyzes 17,20 lyase activity on the same active site, converting 17OH-pregnenolone to DHEA. Progesterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Human P450c17 catalyzes the 17alpha-hydroxylation of pregnenolone to 17OH pregnenolone and of progesterone to 17alpha-OH progesterone; the same P450c17 enzyme also catalyzes 17,20 lyase activity on the same active site, converting 17OH-pregnenolone to DHEA. Progesterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens