Protein Name cytochrome P450 family 17 subfamily A member 1
Organism Homo sapiens
Gene ID 1586
Gene Symbol


UniProt P05093 (CP17A_HUMAN), Q1HB44 (Q1HB44_HUMAN)
Relationships Total Number of functionally related compound(s) : 448
Total Number of Articles : 850

cytochrome P450 family 17 subfamily A member 1

Gene Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]

  • steroid 17-alpha-hydroxylase/17,20 lyase
  • 17-alpha-hydroxyprogesterone aldolase
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