Title : Regulation of cell proliferation and angiotensin II type 2 receptors in R3T3 cells.

Pub. Date : 1998 Aug-Nov

PMID : 9888501






1 Functional Relationships(s)
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1 In conclusion, the present results demonstrated that: 1/ cell proliferation is not correlated with AT2 expression; 2/ growth factors regulate, positively or negatively, AT2 transcription rate, whereas AngII regulates the translation rate of AT2 mRNA; 3/ all the effects of AngII on R3T3 are mediated by AT2 receptors since they are mimicked by the AT2 agonist CGP42112 and blocked by the AT2 antagonist PD123177. PD 123177 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus