Title : Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.

Pub. Date : 1998 Dec 3

PMID : 9853756






1 Functional Relationships(s)
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1 At least three different second messengers, namely diacylglycerol, calcium and cyclic AMP, are able to activate Rap1 by promoting its release of the guanine nucleotide GDP and its binding to GTP. Guanosine Diphosphate RAP1A, member of RAS oncogene family Homo sapiens