Protein Name RAP1A, member of RAS oncogene family
Organism Homo sapiens
Gene ID 5906
Gene Symbol


UniProt P62834 (RAP1A_HUMAN), A8KAH9 (A8KAH9_HUMAN)
Relationships Total Number of functionally related compound(s) : 263
Total Number of Articles : 485

RAP1A, member of RAS oncogene family

Gene Summary

This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

  • ras-related protein Rap-1A
  • GTP-binding protein smg p21A
  • Ras-related protein Krev-1
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