Title : Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12.

Pub. Date : 1998 Dec 18

PMID : 9852069






4 Functional Relationships(s)
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1 We previously characterized KARAP (killer cell activating receptor-associated protein), a novel disulfide-linked tyrosine-phosphorylated dimer that selectively associates with the activating NKR isoforms. Tyrosine TYRO protein tyrosine kinase binding protein Mus musculus
2 We previously characterized KARAP (killer cell activating receptor-associated protein), a novel disulfide-linked tyrosine-phosphorylated dimer that selectively associates with the activating NKR isoforms. Tyrosine TYRO protein tyrosine kinase binding protein Mus musculus
3 Point mutation and transfection studies revealed that KARAP is a novel signaling transmembrane subunit whose transduction function depends on the integrity of an intracytoplasmic immunoreceptor tyrosine-based activation motif. Tyrosine TYRO protein tyrosine kinase binding protein Mus musculus
4 In contrast to previous members of the immunoreceptor tyrosine-based activation motif polypeptide family, KARAP is ubiquitously expressed on hematopoietic and nonhematopoietic cells, suggesting its association with a broad range of activating receptors in a variety of tissues. Tyrosine TYRO protein tyrosine kinase binding protein Mus musculus