Protein Name TYRO protein tyrosine kinase binding protein
Organism Mus musculus
Gene ID 22177
Gene Symbol

Tyrobp

UniProt O54885 (TYOBP_MOUSE), Q3U419 (Q3U419_MOUSE)
Relationships Total Number of functionally related compound(s) : 32
Total Number of Articles : 55
Description

TYRO protein tyrosine kinase binding protein

Gene Summary

Enables signaling receptor binding activity. Involved in several processes, including myeloid cell activation involved in immune response; regulation of cytokine production; and regulation of lymphocyte activation. Acts upstream of or within osteoclast differentiation and regulation of osteoclast development. Located in cell surface. Is expressed in blood vessel; brain; central nervous system; corpus callosum; and embryo. Used to study Nasu-Hakola disease. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • TYRO protein tyrosine kinase-binding protein
  • DNAX-activation protein 12
  • KAR-associated protein
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Properties