Title : Quantitative analysis of von Willebrand factor and its propeptide in plasma in acquired von Willebrand syndrome.

Pub. Date : 1998 Sep

PMID : 9759633






4 Functional Relationships(s)
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1 Measurement of the von Willebrand factor (vWF) propeptide, also known as von Willebrand antigen II, has been suggested to be helpful in the discrimination of congenital von Willebrand disease type I from type 2 and in assessing the extent of activation of the endothelium. propeptide von Willebrand factor Homo sapiens
2 Measurement of the von Willebrand factor (vWF) propeptide, also known as von Willebrand antigen II, has been suggested to be helpful in the discrimination of congenital von Willebrand disease type I from type 2 and in assessing the extent of activation of the endothelium. propeptide von Willebrand factor Homo sapiens
3 In contrast, propeptide levels were significantly higher in AvWS (11.4+/-1.1 vs 4.7+/-0.2 nM, p <0.001), probably reflecting a compensatory increase in vWF synthesis or increased perturbation of the endothelium in AvWS. propeptide von Willebrand factor Homo sapiens
4 Measurement of propeptide levels may provide additional information in AvWS as to whether decreased levels of mature vWF in the circulation are due to a decrease in synthesis or due to an accelerated removal of vWF from the circulation. propeptide von Willebrand factor Homo sapiens