Pub. Date : 1998 May
PMID : 9751146
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Delta9-tetrahydrocannabinol increases sequence-specific AP-1 DNA-binding activity and Fos-related antigens in the rat brain. | Dronabinol | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | One hour after the intraperitoneal administration of delta9-THC at a dose of 10 or 15 mg/kg, AP-1 DNA-binding activity in the nucleus accumbens increased by 33 and 49%, respectively, while Western blot showed an increase in both c-Fos, FosB, Fra-1 (Fos-related antigen) and Fra-2. | Dronabinol | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | The effect of delta9-THC on the AP-1 DNA binding and the Fos-related antigens in the nucleus accumbens was blocked by the specific cannabinoid antagonist SR141716 A (3 mg/kg i.p.). | Dronabinol | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | The results indicate that delta9-THC activates gene coding for AP-1 DNA-binding proteins by acting on cannabinoid receptors, and induces a different transcriptional program on the early-immediate gene of the Fos family, in different areas in the rat brain, suggesting that this mechanism might be involved in the central actions of cannabinoids. | Dronabinol | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |