Title : Prosubstrates of CYP3A4, the major human hepatic cytochrome P450: transformation into substrates by other P450 isoforms.

Pub. Date : 1998 Jun 1

PMID : 9714305






2 Functional Relationships(s)
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1 When reconstituted CYP3A4 was added to an ongoing incubation containing reconstituted 2C19, stimulation of catechol formation occurred. catechol cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Cumulative evidence demonstrates that the stimulation of catechol formation resulted from CYP3A4-mediated ortho-hydroxylation of the phenolic metabolite(s) generated by CYP2C19. catechol cytochrome P450 family 3 subfamily A member 4 Homo sapiens