Title : Triggering of CD40 antigen inhibits fludarabine-induced apoptosis in B chronic lymphocytic leukemia cells.

Pub. Date : 1998 Aug 1

PMID : 9680368






2 Functional Relationships(s)
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1 After exposure to fludarabine, NF-kappaB/Rel complexes were decreased in the nuclei. fludarabine nuclear factor kappa B subunit 1 Homo sapiens
2 These results suggest that CD40 triggering in vivo could counteract the apoptotic effect of fludarabine on B-CLL cells and that its neutralization, or the use of NF-kappaB/Rel inhibitors, could improve the therapeutic effect of fludarabine. fludarabine nuclear factor kappa B subunit 1 Homo sapiens