Title : Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells.

Pub. Date : 1998 Jun 15

PMID : 9616159






3 Functional Relationships(s)
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1 Death-inducing ligands (DILs) such as tumor necrosis factor alpha (TNFalpha) or the cytotoxic drug doxorubicin have been shown to activate a nuclear factor kappaB (NFkappaB)-dependent program that may rescue cells from apoptosis induction. Doxorubicin nuclear factor kappa B subunit 1 Homo sapiens
2 Death-inducing ligands (DILs) such as tumor necrosis factor alpha (TNFalpha) or the cytotoxic drug doxorubicin have been shown to activate a nuclear factor kappaB (NFkappaB)-dependent program that may rescue cells from apoptosis induction. Doxorubicin nuclear factor kappa B subunit 1 Homo sapiens
3 Moreover, both in cell lines and in primary leukemia cells that are resistant towards induction of apoptosis by DILs and doxorubicin, antagonization of NFkappaB activity partially restored apoptosis sensitivity. Doxorubicin nuclear factor kappa B subunit 1 Homo sapiens