Pub. Date : 1998 Apr
PMID : 9563900
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin 6 differentially potentiates the antitumor effects of taxol and vinblastine in U266 human myeloma cells. | Paclitaxel | interleukin 6 | Homo sapiens |
| 2 | In the presence of IL-6, the DNA distribution pattern induced by Taxol or vinblastine was altered. | Paclitaxel | interleukin 6 | Homo sapiens |
| 3 | Whereas IL-6 augmented the sub-G1 fraction and G2-M phase for Taxol-treated cells, only the G2-M phase was increased for vinblastine-treated cells. | Paclitaxel | interleukin 6 | Homo sapiens |
| 4 | In the presence of IL-6, the number of cells containing microtubule asters increased for Taxol treatment, but not for vinblastine treatment. | Paclitaxel | interleukin 6 | Homo sapiens |
| 5 | These data indicate that IL-6 leads to differential modulation of the cytotoxicity of Taxol and vinblastine in U266 cells. | Paclitaxel | interleukin 6 | Homo sapiens |
| 6 | Furthermore, our data suggest that the microtubule-associated form of mitogen-activated protein kinase may play a role in IL-6-mediated enhancement of the cytotoxicity of Taxol. | Paclitaxel | interleukin 6 | Homo sapiens |