PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9563900-0 1998 Interleukin 6 differentially potentiates the antitumor effects of taxol and vinblastine in U266 human myeloma cells. Paclitaxel 66-71 interleukin 6 Homo sapiens 0-13 9563900-6 1998 In the presence of IL-6, the DNA distribution pattern induced by Taxol or vinblastine was altered. Paclitaxel 65-70 interleukin 6 Homo sapiens 19-23 9563900-7 1998 Whereas IL-6 augmented the sub-G1 fraction and G2-M phase for Taxol-treated cells, only the G2-M phase was increased for vinblastine-treated cells. Paclitaxel 62-67 interleukin 6 Homo sapiens 8-12 9563900-11 1998 In the presence of IL-6, the number of cells containing microtubule asters increased for Taxol treatment, but not for vinblastine treatment. Paclitaxel 89-94 interleukin 6 Homo sapiens 19-23 9563900-12 1998 These data indicate that IL-6 leads to differential modulation of the cytotoxicity of Taxol and vinblastine in U266 cells. Paclitaxel 86-91 interleukin 6 Homo sapiens 25-29 9563900-14 1998 Furthermore, our data suggest that the microtubule-associated form of mitogen-activated protein kinase may play a role in IL-6-mediated enhancement of the cytotoxicity of Taxol. Paclitaxel 171-176 interleukin 6 Homo sapiens 122-126