Pub. Date : 1998 Jan
PMID : 9438385
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Taxol-induced p34cdc2 kinase activation and apoptosis inhibited by 12-O-tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 2 | Here, we show that Taxol induced p34cdc2 kinase activity with a peak at 6 h in human breast carcinoma MCF-7 cells. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 3 | Olomoucine, a potent p34cdc2 inhibitor, effectively prevented Taxol-induced p34cdc2 kinase activation and subsequent apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 4 | Olomoucine, a potent p34cdc2 inhibitor, effectively prevented Taxol-induced p34cdc2 kinase activation and subsequent apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 5 | Furthermore, the treatment of cells with cyclin B1-specific antisense oligonucleotide also blocked Taxol-induced apoptosis, suggesting that cyclin B1-associated p34cdc2 kinase plays an important role in the induction of apoptosis by Taxol. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 6 | Furthermore, the treatment of cells with cyclin B1-specific antisense oligonucleotide also blocked Taxol-induced apoptosis, suggesting that cyclin B1-associated p34cdc2 kinase plays an important role in the induction of apoptosis by Taxol. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 7 | TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 8 | TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 9 | These findings suggest that modulation of protein kinase C signaling can protect against Taxol-induced cell death by inhibiting p34cdc2 kinase activation. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |