PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9438385-0	1998	Taxol-induced p34cdc2 kinase activation and apoptosis inhibited by 12-O-tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells.	Paclitaxel	0-5	cyclin dependent kinase 1	Homo sapiens	14-21	
9438385-3	1998	Here, we show that Taxol induced p34cdc2 kinase activity with a peak at 6 h in human breast carcinoma MCF-7 cells.	Paclitaxel	19-24	cyclin dependent kinase 1	Homo sapiens	33-40	
9438385-5	1998	Olomoucine, a potent p34cdc2 inhibitor, effectively prevented Taxol-induced p34cdc2 kinase activation and subsequent apoptosis.	Paclitaxel	62-67	cyclin dependent kinase 1	Homo sapiens	21-28	
9438385-5	1998	Olomoucine, a potent p34cdc2 inhibitor, effectively prevented Taxol-induced p34cdc2 kinase activation and subsequent apoptosis.	Paclitaxel	62-67	cyclin dependent kinase 1	Homo sapiens	76-83	
9438385-6	1998	Furthermore, the treatment of cells with cyclin B1-specific antisense oligonucleotide also blocked Taxol-induced apoptosis, suggesting that cyclin B1-associated p34cdc2 kinase plays an important role in the induction of apoptosis by Taxol.	Paclitaxel	99-104	cyclin dependent kinase 1	Homo sapiens	161-168	
9438385-6	1998	Furthermore, the treatment of cells with cyclin B1-specific antisense oligonucleotide also blocked Taxol-induced apoptosis, suggesting that cyclin B1-associated p34cdc2 kinase plays an important role in the induction of apoptosis by Taxol.	Paclitaxel	233-238	cyclin dependent kinase 1	Homo sapiens	161-168	
9438385-8	1998	TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1.	Paclitaxel	14-19	cyclin dependent kinase 1	Homo sapiens	43-50	
9438385-8	1998	TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1.	Paclitaxel	14-19	cyclin dependent kinase 1	Homo sapiens	119-126	
9438385-10	1998	These findings suggest that modulation of protein kinase C signaling can protect against Taxol-induced cell death by inhibiting p34cdc2 kinase activation.	Paclitaxel	89-94	cyclin dependent kinase 1	Homo sapiens	128-135