Title : Investigation of the role of nitric oxide and cyclic GMP in both the activation and inhibition of human neutrophils.

Pub. Date : 1997 Nov

PMID : 9401778






2 Functional Relationships(s)
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1 A role for NO as a mediator of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced chemotaxis was supported by the finding that the NO synthase (NOS) inhibitor L-NMMA (500 microM) inhibited chemotaxis; EC50 for fMLP 28.76 +/- 5.62 and 41.13 +/- 4.77 pmol/10(6) cells with and without L-NMMA, respectively. omega-N-Methylarginine nitric oxide synthase 2 Homo sapiens
2 A role for NO as a mediator of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced chemotaxis was supported by the finding that the NO synthase (NOS) inhibitor L-NMMA (500 microM) inhibited chemotaxis; EC50 for fMLP 28.76 +/- 5.62 and 41.13 +/- 4.77 pmol/10(6) cells with and without L-NMMA, respectively. omega-N-Methylarginine nitric oxide synthase 2 Homo sapiens