Pub. Date : 1997 Apr
PMID : 9170147
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4"-hydroxylation activities in livers of Japanese and Caucasian populations. | Tolbutamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | Good correlations were found between levels of CYP2C9 and activities of tolbutamide methyl hydroxylation (r = 0.77) and between levels of CYP2C19 and activities of S-mephenytoin 4"-hydroxylation (r = 0.86) in liver microsomes of the human samples examined. | Tolbutamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | Tolbutamide methyl hydroxylation activities were lower in human samples with the Leu359 allele of CYP2C9 than those with the Cys144 allele and wild-type (Arg144-Ile359); the former type showed slightly higher K(m) values. | Tolbutamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |