Title : Identification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak/STAT pathway.

Pub. Date : 1997 Jun 6

PMID : 9169451






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Unexpectedly, the 5-HT2A receptor is able to activate another signaling pathway; it triggers a rapid and transient tyrosine phosphorylation of Jak2 kinase in response to serotonin. Tyrosine Janus kinase 2 Rattus norvegicus
2 Jak2 auto-phosphorylation is followed by the tyrosine phosphorylation of STAT3 (signal transducers and activators of transcription) and its translocation into the nucleus. Tyrosine Janus kinase 2 Rattus norvegicus