Title : Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases.

Pub. Date : 1997 May 9

PMID : 9139732






3 Functional Relationships(s)
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1 Notably, two neighboring pRB phosphate acceptors, threonine 821 and threonine 826, which have previously been implicated in the regulation of LXCXE protein binding, are phosphorylated by different CDKs. Threonine cyclin dependent kinase 2 Homo sapiens
2 Notably, two neighboring pRB phosphate acceptors, threonine 821 and threonine 826, which have previously been implicated in the regulation of LXCXE protein binding, are phosphorylated by different CDKs. Threonine cyclin dependent kinase 2 Homo sapiens
3 We demonstrate that phosphorylation by either CDK2-cyclin A, which phosphorylates T821, or CDK4-cyclin D1, which phosphorylates threonine 826, can disable pRB for subsequent binding of an LXCXE protein. Threonine cyclin dependent kinase 2 Homo sapiens