Pub. Date : 1997 Feb 7
PMID : 9065732
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epidermal growth factor receptor signaling cascade as target for tyrphostin (RG 50864) in epithelial cells. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 2 | Tyrphostins are synthetic compounds that have been described as in vitro inhibitors of epidermal growth factor receptor (EGF-R) tyrosine kinase activity. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 3 | Tyrphostins are synthetic compounds that have been described as in vitro inhibitors of epidermal growth factor receptor (EGF-R) tyrosine kinase activity. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 4 | However, these compounds appear to be readily incorporated, which suggests that tyrphostin acts indirectly on EGF-R. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 5 | Because tyrphostin has been shown to be an inhibitor of p185erbB2 and EGF-R in vitro, this finding indicates that the tyrphostin effect on p185erbB2(V-E) and EGF-R was the result of an indirect mechanism in transfected cells. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 6 | Because tyrphostin has been shown to be an inhibitor of p185erbB2 and EGF-R in vitro, this finding indicates that the tyrphostin effect on p185erbB2(V-E) and EGF-R was the result of an indirect mechanism in transfected cells. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 7 | Because tyrphostin has been shown to be an inhibitor of p185erbB2 and EGF-R in vitro, this finding indicates that the tyrphostin effect on p185erbB2(V-E) and EGF-R was the result of an indirect mechanism in transfected cells. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 8 | Because tyrphostin has been shown to be an inhibitor of p185erbB2 and EGF-R in vitro, this finding indicates that the tyrphostin effect on p185erbB2(V-E) and EGF-R was the result of an indirect mechanism in transfected cells. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 9 | We conclude that whereas tyrphostins were designed to inhibit EGF-R tyrosine kinase activity, under our conditions EGF-R is not a physiological target for tyrphostin, nor is one of its related protein tyrosine kinases, p185erbB2(V-E). | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 10 | We conclude that whereas tyrphostins were designed to inhibit EGF-R tyrosine kinase activity, under our conditions EGF-R is not a physiological target for tyrphostin, nor is one of its related protein tyrosine kinases, p185erbB2(V-E). | Tyrphostins | epidermal growth factor receptor | Homo sapiens |