Pub. Date : 1997 Jan
PMID : 8977428
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Corticotropin-releasing hormone and proopiomelanocortin gene expression is altered selectively in the male rat fetal thymus by maternal alcohol consumption. | Alcohols | corticotropin releasing hormone | Rattus norvegicus |
| 2 | The present study was carried out to investigate how hormonal changes caused by chronic alcohol exposure of rats during the late period of gestation are coordinated with neuroendocrine functions of the fetal thymus, namely thymic expression of CRH and POMC genes. | Alcohols | corticotropin releasing hormone | Rattus norvegicus |
| 3 | Furthermore, fetal alcohol exposure (FAE) resulted in a significant increase in thymic CRH and a decrease in thymic POMC expression in the male fetuses only, specifically on embryonic day 19. | Alcohols | corticotropin releasing hormone | Rattus norvegicus |
| 4 | These data suggest that the sexually dimorphic effect of FAE on the fetal thymic POMC and CRH expression in males is driven by testosterone and may be related, therefore, to the presence of alcohol at the time of the prenatal testosterone surge in the male fetuses. | Alcohols | corticotropin releasing hormone | Rattus norvegicus |