Title : The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism.

Pub. Date : 1996 Aug

PMID : 8873220






3 Functional Relationships(s)
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1 The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Tolbutamide cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 Studies in a recombinant yeast expression system showed that the Leu359 variant had the highest Km and the lowest Vmac for hydroxylation of tolbutamide of all the CYP2C9 allelic variants. Tolbutamide cytochrome P450 family 2 subfamily C member 9 Homo sapiens
3 The present data suggest that the incidence of the Leu359 allelic variant of CYP2C9 may account for the occurrence of poor metabolizers of tolbutamide. Tolbutamide cytochrome P450 family 2 subfamily C member 9 Homo sapiens