Pub. Date : 1996 Aug
PMID : 8873220
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. | Tolbutamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
2 | Studies in a recombinant yeast expression system showed that the Leu359 variant had the highest Km and the lowest Vmac for hydroxylation of tolbutamide of all the CYP2C9 allelic variants. | Tolbutamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
3 | The present data suggest that the incidence of the Leu359 allelic variant of CYP2C9 may account for the occurrence of poor metabolizers of tolbutamide. | Tolbutamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |