PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8873220-0 1996 The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Tolbutamide 53-64 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 16-22 8873220-11 1996 Studies in a recombinant yeast expression system showed that the Leu359 variant had the highest Km and the lowest Vmac for hydroxylation of tolbutamide of all the CYP2C9 allelic variants. Tolbutamide 140-151 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 163-169 8873220-13 1996 The present data suggest that the incidence of the Leu359 allelic variant of CYP2C9 may account for the occurrence of poor metabolizers of tolbutamide. Tolbutamide 139-150 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 77-83