Pub. Date : 1995 Oct
PMID : 8654202
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gestodene, a mechanism-based inhibitor of CYP3A isozymes, showed a concentration-dependent inhibition of the oxidative metabolism of [14C]finasteride. | Finasteride | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Inhibitors of CYP3A isozymes inhibited the oxidation of omega-aldehyde finasteride in a concentration-dependent manner; an increase in the reduction was also observed, presumably caused by inhibition of the competitive oxidative reaction. | Finasteride | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Consistent with these results, only microsomes containing human recombinant CYP3A4 catalyzed the oxidation of omega-aldehyde finasteride to omega-oic acid finasteride. | Finasteride | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Consistent with these results, only microsomes containing human recombinant CYP3A4 catalyzed the oxidation of omega-aldehyde finasteride to omega-oic acid finasteride. | Finasteride | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | These results indicate that the oxidation of omega-aldehyde finasteride was NADPH-dependent and was mediated at least in part by CYP3A4. | Finasteride | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |