Title : Evaluation of cathepsins D and G and EC 3.4.24.15 as candidate beta-secretase proteases using peptide and amyloid precursor protein substrates.

Pub. Date : 1996 Jun

PMID : 8632167






1 Functional Relationships(s)
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1 We have isolated and purified a brain-derived activity that cleaves the synthetic peptide substrate SEVKMDAEF between methionine and aspartate residues, as required to generate the amino-terminus of beta-amyloid peptide. Aspartic Acid amyloid beta precursor protein Homo sapiens