CPRiL

Protein Name	amyloid beta precursor protein
Organism	Homo sapiens
Gene ID	351
Gene Symbol	APP
UniProt	P05067 (A4_HUMAN), A0A0A0MRG2 (A0A0A0MRG2_HUMAN), B4DGD0 (B4DGD0_HUMAN), B4DJT9 (B4DJT9_HUMAN), A0A140VJC8 (A0A140VJC8_HUMAN), E9PG40 (E9PG40_HUMAN)
Relationships	Total Number of functionally related compound(s) : 3390 Total Number of Articles : 6202
Description	amyloid beta precursor protein
Gene Summary	This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
synonyms	amyloid-beta precursor protein alzheimer disease amyloid A4 protein homolog alzheimer disease amyloid protein amyloid beta (A4) precursor protein amyloid beta A4 protein amyloid precursor protein beta-amyloid peptide beta-amyloid peptide(1-40) beta-amyloid peptide(1-42) beta-amyloid precursor protein cerebral vascular amyloid peptide peptidase nexin-II protease nexin-II testicular tissue protein Li 2 AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 alpha-sAPP preA4 Click to show/hide the synonyms
Properties