Protein Name amyloid beta precursor protein
Organism Homo sapiens
Gene ID 351
Gene Symbol


UniProt P05067 (A4_HUMAN), A0A0A0MRG2 (A0A0A0MRG2_HUMAN), B4DGD0 (B4DGD0_HUMAN), B4DJT9 (B4DJT9_HUMAN), A0A140VJC8 (A0A140VJC8_HUMAN), E9PG40 (E9PG40_HUMAN)
Relationships Total Number of functionally related compound(s) : 3390
Total Number of Articles : 6202

amyloid beta precursor protein

Gene Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

  • amyloid-beta precursor protein
  • alzheimer disease amyloid A4 protein homolog
  • alzheimer disease amyloid protein
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