Title : Effect of endocrine therapy on growth of T61 human breast cancer xenografts is directly correlated to a specific down-regulation of insulin-like growth factor II (IGF-II).

Pub. Date : 1993

PMID : 8435211






2 Functional Relationships(s)
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1 Here we report on the effect of E2 and tamoxifen (TAM) on IGF-II mRNA and protein expression in the ER+T61 human breast cancer xenograft. Tamoxifen insulin like growth factor 2 Homo sapiens
2 TAM treatment of T61 tumours, which results in inhibition of tumour growth without tumour regression, reduced IGF-II mRNA expression approximately 10-fold after 48 h of treatment. Tamoxifen insulin like growth factor 2 Homo sapiens