Title : Plasminogen activator inhibitor-1 synthesis in the human hepatoma cell line Hep G2. Metformin inhibits the stimulating effect of insulin.

Pub. Date : 1993 May

PMID : 8387542






2 Functional Relationships(s)
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1 The effect of metformin, a dimethyl-substituted biguanide, known to lower plasma insulin and PAI-1 levels in vivo was concomitantly evaluated. Metformin serpin family E member 1 Homo sapiens
2 The results indicate that PAI-1 synthesis in presence of insulin is markedly increased in down-regulated cells, and that metformin inhibits this effect by acting at the cellular level. Metformin serpin family E member 1 Homo sapiens