PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8387542-6 1993 The effect of metformin, a dimethyl-substituted biguanide, known to lower plasma insulin and PAI-1 levels in vivo was concomitantly evaluated. Metformin 14-23 serpin family E member 1 Homo sapiens 93-98 8387542-11 1993 The results indicate that PAI-1 synthesis in presence of insulin is markedly increased in down-regulated cells, and that metformin inhibits this effect by acting at the cellular level. Metformin 121-130 serpin family E member 1 Homo sapiens 26-31