Pub. Date : 1994 May 3
PMID : 8172889
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Roles of disulfide bonds in recombinant human interleukin 6 conformation. | Disulfides | interleukin 6 | Homo sapiens |
| 2 | Human IL-6 has two disulfide bonds linking Cys45 to Cys51 and Cys74 to Cys84, respectively. | Disulfides | interleukin 6 | Homo sapiens |
| 3 | To address the structural importance of these disulfide bonds in the formation and stabilization of IL-6 secondary and tertiary structures, we have generated a panel of disulfide bond-deficient rIL-6 analogs both by chemical reduction and alkylation as well as by site-directed mutagenesis. | Disulfides | interleukin 6 | Homo sapiens |
| 4 | Our results suggest that the second disulfide bridge plays a critical role in maintaining the spatial relationship between the putative IL-6 A and D helices. | Disulfides | interleukin 6 | Homo sapiens |