PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8074700-0 1994 Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity. Acetaminophen 52-65 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 19-25 8074700-2 1994 In non-induced mice, 150 mg/kg APAP caused minimal hepatotoxicity and loss of CYP2E1- but not CYP1A2-dependent activity. Acetaminophen 31-35 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 94-100 8074700-3 1994 In contrast, 400 mg/kg APAP was hepatotoxic and diminished both CYP2E1 and CYP1A2 activities. Acetaminophen 23-27 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 75-81 8074700-5 1994 In beta-napthaflavone-pretreated mice, CYP1A2 activity was decreased only by the high dose of APAP, and covalent binding was > 2-fold higher at the high APAP dose. Acetaminophen 94-98 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 39-45