Pub. Date : 1994 Jul 15
PMID : 8042983
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. | phosphatidylinositol 3,4,5-triphosphate | coagulation factor II, thrombin | Homo sapiens |
| 2 | Platelets accumulate PtdIns(3,4,5)P3 and PtdIns(3,4)P2 in response to thrombin and thrombin-receptor-directed peptide in a GTP-dependent manner. | phosphatidylinositol 3,4,5-triphosphate | coagulation factor II, thrombin | Homo sapiens |
| 3 | Platelets accumulate PtdIns(3,4,5)P3 and PtdIns(3,4)P2 in response to thrombin and thrombin-receptor-directed peptide in a GTP-dependent manner. | phosphatidylinositol 3,4,5-triphosphate | coagulation factor II, thrombin | Homo sapiens |
| 4 | We have examined the metabolic route by which PtdIns(3,4,5)P3 and PtdIns(3,4)P2 are synthesized by briefly (10 min) incubating platelets with high activities of [32P]Pi, followed by 20 or 60 s exposure to thrombin, and analysing the relative radioactivities of the individual phosphate groups in the resulting labelled PtdIns(3,4,5)P3 and PtdIns(3,4)P2. | phosphatidylinositol 3,4,5-triphosphate | coagulation factor II, thrombin | Homo sapiens |