Pub. Date : 1994 Jul
PMID : 8013385
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Studies from this and other laboratories have shown that interleukin-1 alpha (IL-1 alpha) stimulates corticosterone and prostaglandin (PG) release from primary cultures of rat adrenal cells. | Corticosterone | interleukin 1 alpha | Rattus norvegicus |
| 2 | Studies from this and other laboratories have shown that interleukin-1 alpha (IL-1 alpha) stimulates corticosterone and prostaglandin (PG) release from primary cultures of rat adrenal cells. | Corticosterone | interleukin 1 alpha | Rattus norvegicus |
| 3 | A previous report from our laboratory (1) indicated involvement of the alpha-adrenergic system in IL-1 alpha-stimulated corticosterone secretion from primary cultures of rat adrenal cells. | Corticosterone | interleukin 1 alpha | Rattus norvegicus |
| 4 | IL-1 alpha significantly increased (P < 0.05) epinephrine, PGE2, and corticosterone levels above those in medium-treated controls from primary adrenal cells. | Corticosterone | interleukin 1 alpha | Rattus norvegicus |
| 5 | In the presence of the alpha-adrenergic antagonist phentolamine (10 microM), IL-1 alpha-stimulated (P < 0.05) corticosterone release was inhibited, whereas IL-1 alpha-induced PGE2 release was not affected. | Corticosterone | interleukin 1 alpha | Rattus norvegicus |
| 6 | These observations indicate that IL-1 alpha stimulates corticosterone release through an alpha-adrenergic mechanism that is independent of PGE2 release from primary rat adrenal cells. | Corticosterone | interleukin 1 alpha | Rattus norvegicus |