PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8013385-1 1994 Studies from this and other laboratories have shown that interleukin-1 alpha (IL-1 alpha) stimulates corticosterone and prostaglandin (PG) release from primary cultures of rat adrenal cells. Corticosterone 101-115 interleukin 1 alpha Rattus norvegicus 57-76 8013385-1 1994 Studies from this and other laboratories have shown that interleukin-1 alpha (IL-1 alpha) stimulates corticosterone and prostaglandin (PG) release from primary cultures of rat adrenal cells. Corticosterone 101-115 interleukin 1 alpha Rattus norvegicus 78-88 8013385-2 1994 A previous report from our laboratory (1) indicated involvement of the alpha-adrenergic system in IL-1 alpha-stimulated corticosterone secretion from primary cultures of rat adrenal cells. Corticosterone 120-134 interleukin 1 alpha Rattus norvegicus 98-108 8013385-9 1994 IL-1 alpha significantly increased (P < 0.05) epinephrine, PGE2, and corticosterone levels above those in medium-treated controls from primary adrenal cells. Corticosterone 72-86 interleukin 1 alpha Rattus norvegicus 0-10 8013385-10 1994 In the presence of the alpha-adrenergic antagonist phentolamine (10 microM), IL-1 alpha-stimulated (P < 0.05) corticosterone release was inhibited, whereas IL-1 alpha-induced PGE2 release was not affected. Corticosterone 113-127 interleukin 1 alpha Rattus norvegicus 77-87 8013385-13 1994 These observations indicate that IL-1 alpha stimulates corticosterone release through an alpha-adrenergic mechanism that is independent of PGE2 release from primary rat adrenal cells. Corticosterone 55-69 interleukin 1 alpha Rattus norvegicus 33-43