Title : The 5-HT3 antagonist, BRL 46470 does not attenuate m-chlorophenylpiperazine (mCPP)-induced changes in human volunteers.

Pub. Date : 1994 Sep 1

PMID : 7993957






2 Functional Relationships(s)
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1 We have assessed whether pretreatment with the 5-HT3 receptor antagonist BRL 46470 (1 mg orally) attenuates the increase in anxiety induced in healthy volunteers by intravenous infusion of m-chlorophenylpiperazine (mCPP: 0.08 mg/kg over 2 min). 1-(3-chlorophenyl)piperazine 5-hydroxytryptamine receptor 3A Homo sapiens
2 We have assessed whether pretreatment with the 5-HT3 receptor antagonist BRL 46470 (1 mg orally) attenuates the increase in anxiety induced in healthy volunteers by intravenous infusion of m-chlorophenylpiperazine (mCPP: 0.08 mg/kg over 2 min). 1-(3-chlorophenyl)piperazine 5-hydroxytryptamine receptor 3A Homo sapiens