Protein Name 5-hydroxytryptamine receptor 3A
Organism Homo sapiens
Gene ID 3359
Gene Symbol

HTR3A

UniProt P46098 (5HT3A_HUMAN), B4E398 (B4E398_HUMAN)
Relationships Total Number of functionally related compound(s) : 165
Total Number of Articles : 200
Description

5-hydroxytryptamine receptor 3A

Gene Summary

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

synonyms
  • 5-hydroxytryptamine receptor 3A
  • 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
  • 5-hydroxytryptamine receptor 3
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Properties