Title : Prepro-TRH-(160-169) potentiates gastric acid secretion stimulated by TRH microinjected into the dorsal motor nucleus of the vagus.

Pub. Date : 1994 Jun 6

PMID : 7970152






4 Functional Relationships(s)
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1 Ps4 (100, 150 and 200 ng) co-injected with TRH (50 ng) into the DMN potentiated the acid response to TRH by 14%, 76% and 182% respectively while prepro-TRH-(178-199) (Ps5, 438 ng) had no effect. Dimethylnitrosamine thyrotropin releasing hormone Rattus norvegicus
2 Ps4 (100, 150 and 200 ng) co-injected with TRH (50 ng) into the DMN potentiated the acid response to TRH by 14%, 76% and 182% respectively while prepro-TRH-(178-199) (Ps5, 438 ng) had no effect. Dimethylnitrosamine thyrotropin releasing hormone Rattus norvegicus
3 Ps4 (100, 150 and 200 ng) co-injected with TRH (50 ng) into the DMN potentiated the acid response to TRH by 14%, 76% and 182% respectively while prepro-TRH-(178-199) (Ps5, 438 ng) had no effect. Dimethylnitrosamine thyrotropin releasing hormone Rattus norvegicus
4 These results indicate that Ps4 potentiates TRH in the DMN-evoked gastric acid secretion through an action that is peptide and site specific. Dimethylnitrosamine thyrotropin releasing hormone Rattus norvegicus