Title : Glutamate-induced protein phosphorylation in cerebellar granule cells: role of protein kinase C.

Pub. Date : 1994 Oct

PMID : 7891841






2 Functional Relationships(s)
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1 The effect of glutamate is mimicked by phorbol esters and is markedly reduced by inhibitors of protein kinase C (PKC) such as staurosporine and calphostin C. PP80 has been identified by Western blot analysis as the PKC substrate MARCKS (myristoylated alanine-rich C kinase substrate), while antibody to GAP-43 (growth associated protein-43), the nervous tissue-specific substrate of PKC, failed to recognize PP43. Glutamic Acid myristoylated alanine rich protein kinase C substrate Homo sapiens
2 The effect of glutamate is mimicked by phorbol esters and is markedly reduced by inhibitors of protein kinase C (PKC) such as staurosporine and calphostin C. PP80 has been identified by Western blot analysis as the PKC substrate MARCKS (myristoylated alanine-rich C kinase substrate), while antibody to GAP-43 (growth associated protein-43), the nervous tissue-specific substrate of PKC, failed to recognize PP43. Glutamic Acid myristoylated alanine rich protein kinase C substrate Homo sapiens