Title : Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 2. Effect of varying the heterocyclic ring on in vitro potency.

Pub. Date : 1995 Jan 6

PMID : 7837243






1 Functional Relationships(s)
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1 Several heterocycles, including oxazoline and benzoxazole, afforded extremely potent inhibitors of HNE (1p-r) with nanomolar to subnanomolar Ki values. Benzoxazoles elastase, neutrophil expressed Homo sapiens