Protein Name elastase, neutrophil expressed
Organism Homo sapiens
Gene ID 1991
Gene Symbol


UniProt P08246 (ELNE_HUMAN)
Relationships Total Number of functionally related compound(s) : 945
Total Number of Articles : 965

elastase, neutrophil expressed

Gene Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]

  • neutrophil elastase
  • PMN elastase
  • bone marrow serine protease
Click to show/hide the synonyms