Pub. Date : 1995 Jul 1
PMID : 7602106
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thapsigargin and cyclopiazonic acid initiate rapid and dramatic increases of IL-6 mRNA expression and IL-6 secretion in murine peritoneal macrophages. | cyclopiazonic acid | interleukin 6 | Mus musculus |
| 2 | Thapsigargin and cyclopiazonic acid initiate rapid and dramatic increases of IL-6 mRNA expression and IL-6 secretion in murine peritoneal macrophages. | cyclopiazonic acid | interleukin 6 | Mus musculus |
| 3 | The activity of these inhibitors was linked to an important biologic response, because both cyclopiazonic acid and thapsigargin induced rapid and dramatic increases in IL-6 mRNA expression and secretion. | cyclopiazonic acid | interleukin 6 | Mus musculus |
| 4 | The increased mRNA expression was coupled to translation and secretion of this monokine since cyclopiazonic acid and thapsigargin induced significant increases in IL-6 secretion as early as 2 h, and up to approximately 70-fold increases by 20 h, when compared with control cultures. | cyclopiazonic acid | interleukin 6 | Mus musculus |
| 5 | Taken together, these results demonstrate that both cyclopiazonic acid and thapsigargin generate potent intracellular signals that initiate rapid and dramatic production of IL-6. | cyclopiazonic acid | interleukin 6 | Mus musculus |
| 6 | Both thapsigargin and cyclopiazonic acid increased IL-6 mRNA expression at 15 min in the absence of Ca2+ influx from the extracellular medium. | cyclopiazonic acid | interleukin 6 | Mus musculus |