Title : Nicotine elicits changes in expression of adrenal catecholamine biosynthetic enzymes, neuropeptide Y and immediate early genes by injection but not continuous administration.

Pub. Date : 1995 Aug

PMID : 7494448






3 Functional Relationships(s)
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1 In this study we show that single and repeated injections of nicotine increase the expression of tyrosine hydroxylase (TH), a rate limiting enzyme in the catecholamine biosynthetic pathway. Nicotine tyrosine hydroxylase Rattus norvegicus
2 In this study we show that single and repeated injections of nicotine increase the expression of tyrosine hydroxylase (TH), a rate limiting enzyme in the catecholamine biosynthetic pathway. Nicotine tyrosine hydroxylase Rattus norvegicus
3 These data indicate that activation of several transcription factors and increased expression of TH, DBH, and NPY is dependent on the mode of nicotine administration. Nicotine tyrosine hydroxylase Rattus norvegicus