Protein Name tyrosine hydroxylase
Organism Rattus norvegicus
Gene ID 25085
Gene Symbol

Th

UniProt P04177 (TY3H_RAT)
Relationships Total Number of functionally related compound(s) : 552
Total Number of Articles : 1071
Description

tyrosine hydroxylase

Gene Summary

Enables several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; carboxylic acid metabolic process; and cellular response to nicotine. Located in several cellular components, including cytoplasmic vesicle; perikaryon; and terminal bouton. Used to study Parkinson's disease. Biomarker of several diseases, including brain disease (multiple); hyperprolactinemia; hypoglycemia; polycystic ovary syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • tyrosine 3-monooxygenase
  • tyrosine 3-hydroxylase
  • The
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Properties