PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7494448-3 1995 In this study we show that single and repeated injections of nicotine increase the expression of tyrosine hydroxylase (TH), a rate limiting enzyme in the catecholamine biosynthetic pathway. Nicotine 61-69 tyrosine hydroxylase Rattus norvegicus 97-117 7494448-3 1995 In this study we show that single and repeated injections of nicotine increase the expression of tyrosine hydroxylase (TH), a rate limiting enzyme in the catecholamine biosynthetic pathway. Nicotine 61-69 tyrosine hydroxylase Rattus norvegicus 119-121 7494448-8 1995 These data indicate that activation of several transcription factors and increased expression of TH, DBH, and NPY is dependent on the mode of nicotine administration. Nicotine 142-150 tyrosine hydroxylase Rattus norvegicus 97-99