Title : Regulation of glutathione transferase and DT-diaphorase mRNAs in persistent hepatocyte nodules during chemical hepatocarcinogenesis.

Pub. Date : 1984 Aug

PMID : 6433344






2 Functional Relationships(s)
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1 When animals were administered 3-methylcholanthrene, a typical inducer of these mRNAs in normal animals, a further increase in the glutathione transferase Yb mRNA(s) and DT-diaphorase mRNA was observed in the nodules; however, the Ya/Yc mRNA levels remained unaffected. Methylcholanthrene NAD(P)H quinone dehydrogenase 1 Rattus norvegicus
2 Our data indicate that during chemically induced neoplastic transformation, the mRNA levels for the Yb subunit of glutathione transferase and DT-diaphorase are increased in the nodules but still retain the capacity to be regulated by 3-methylcholanthrene. Methylcholanthrene NAD(P)H quinone dehydrogenase 1 Rattus norvegicus