Title : Thrombin and activators of protein kinase C modulate secretory responses of permeabilised human platelets induced by Ca2+.

Pub. Date : 1984 Sep 3

PMID : 6236084






3 Functional Relationships(s)
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1 In contrast, thrombin shifts the dose/response curve for Ca2+-induced [14C]serotonin secretion to the left and has little effect on the maximal extent of this response even when this extent is reduced by use of a non-saturating concentration of MgATP2-. Carbon-14 coagulation factor II, thrombin Homo sapiens
2 Activators of protein kinase C have previously been shown to mimic quantitatively the effect of thrombin on [14C]serotonin secretion induced by Ca2+ [D. E. Knight & M. C. Scrutton (1984) Nature (Lond.) Carbon-14 coagulation factor II, thrombin Homo sapiens
3 The EC50 for thrombin observed for enhancement of [14C]serotonin and beta-N-acetylglucosaminidase secretion is in the same range as that obtained for intact platelets under comparable conditions [D. E. Knight, T. J. Hallam & M. C. Scrutton (1982) Nature (Lond.) Carbon-14 coagulation factor II, thrombin Homo sapiens