Pub. Date : 2022 Apr 7
PMID : 35527434
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Objective: To explore the relationship between NLRP3-mediated pyroptosis and olfactory dysfunction (OD) in allergic rhinitis (AR), and to evaluate the therapeutic potential of CY-09, a selective NLRP3 inhibitor for OD. | CY5.5 cyanine dye | NLR family, pyrin domain containing 3 | Mus musculus | ||
2 | Objective: To explore the relationship between NLRP3-mediated pyroptosis and olfactory dysfunction (OD) in allergic rhinitis (AR), and to evaluate the therapeutic potential of CY-09, a selective NLRP3 inhibitor for OD. | CY5.5 cyanine dye | NLR family, pyrin domain containing 3 | Mus musculus | ||
3 | CY-09 could significantly reduce the level of NLRP3, caspase-1, GSDMD, IL-1beta and IL-18 expression, and inhibite the activation of microglia and astrocytes in the olfactory bulb tissues (all P<0.05). | CY5.5 cyanine dye | NLR family, pyrin domain containing 3 | Mus musculus | ||
4 | CY-09 could improve the olfactory function in AR mice, which may be related to blocking the NLRP3-mediated pyroptosis. | CY5.5 cyanine dye | NLR family, pyrin domain containing 3 | Mus musculus |