Title : [Effects of NLRP3-mediated pyroptosis on olfaction dysfunction in allergic rhinitis].

Pub. Date : 2022 Apr 7

PMID : 35527434






4 Functional Relationships(s)
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1 Objective: To explore the relationship between NLRP3-mediated pyroptosis and olfactory dysfunction (OD) in allergic rhinitis (AR), and to evaluate the therapeutic potential of CY-09, a selective NLRP3 inhibitor for OD. CY5.5 cyanine dye NLR family, pyrin domain containing 3 Mus musculus
2 Objective: To explore the relationship between NLRP3-mediated pyroptosis and olfactory dysfunction (OD) in allergic rhinitis (AR), and to evaluate the therapeutic potential of CY-09, a selective NLRP3 inhibitor for OD. CY5.5 cyanine dye NLR family, pyrin domain containing 3 Mus musculus
3 CY-09 could significantly reduce the level of NLRP3, caspase-1, GSDMD, IL-1beta and IL-18 expression, and inhibite the activation of microglia and astrocytes in the olfactory bulb tissues (all P<0.05). CY5.5 cyanine dye NLR family, pyrin domain containing 3 Mus musculus
4 CY-09 could improve the olfactory function in AR mice, which may be related to blocking the NLRP3-mediated pyroptosis. CY5.5 cyanine dye NLR family, pyrin domain containing 3 Mus musculus