PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35527434-1 2022 Objective: To explore the relationship between NLRP3-mediated pyroptosis and olfactory dysfunction (OD) in allergic rhinitis (AR), and to evaluate the therapeutic potential of CY-09, a selective NLRP3 inhibitor for OD. CY5.5 cyanine dye 176-181 NLR family, pyrin domain containing 3 Mus musculus 47-52 35527434-1 2022 Objective: To explore the relationship between NLRP3-mediated pyroptosis and olfactory dysfunction (OD) in allergic rhinitis (AR), and to evaluate the therapeutic potential of CY-09, a selective NLRP3 inhibitor for OD. CY5.5 cyanine dye 176-181 NLR family, pyrin domain containing 3 Mus musculus 195-200 35527434-11 2022 CY-09 could significantly reduce the level of NLRP3, caspase-1, GSDMD, IL-1beta and IL-18 expression, and inhibite the activation of microglia and astrocytes in the olfactory bulb tissues (all P<0.05). CY5.5 cyanine dye 0-5 NLR family, pyrin domain containing 3 Mus musculus 46-51 35527434-13 2022 CY-09 could improve the olfactory function in AR mice, which may be related to blocking the NLRP3-mediated pyroptosis. CY5.5 cyanine dye 0-5 NLR family, pyrin domain containing 3 Mus musculus 92-97