Protein Name NLR family, pyrin domain containing 3
Organism Mus musculus
Gene ID 216799
Gene Symbol


UniProt Q8R4B8 (NLRP3_MOUSE)
Relationships Total Number of functionally related compound(s) : 1325
Total Number of Articles : 2115

NLR family, pyrin domain containing 3

Gene Summary

Enables DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of T-helper cell differentiation; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including NLRP3 inflammasome complex assembly; activation of cysteine-type endopeptidase activity involved in apoptotic process; and defense response to virus. Located in cytoplasm and nucleus. Part of NLRP3 inflammasome complex. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

  • NACHT, LRR and PYD domains-containing protein 3
  • NACHT/LRR/pyrin domain-containing protein 3
  • PYRIN-containing APAF1-like protein 1
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