Protein Name NLR family, pyrin domain containing 3
Organism Mus musculus
Gene ID 216799
Gene Symbol

Nlrp3

UniProt Q8R4B8 (NLRP3_MOUSE)
Relationships Total Number of functionally related compound(s) : 1325
Total Number of Articles : 2115
Description

NLR family, pyrin domain containing 3

Gene Summary

Enables several functions, including ATP hydrolysis activity; phosphatidylinositol-4-phosphate binding activity; and signaling adaptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of macromolecule biosynthetic process; and response to bacterium. Acts upstream of or within acute inflammatory response; defense response to virus; and regulation of inflammatory response. Located in interphase microtubule organizing center; mitochondrion; and nucleus. Part of NLRP3 inflammasome complex. Is active in membrane. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • NACHT, LRR and PYD domains-containing protein 3
  • NACHT/LRR/pyrin domain-containing protein 3
  • PYRIN-containing APAF1-like protein 1
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Properties